BOSTON (AP) — David Ortiz homered in Boston's eight-run first inning, then got into a bench-clearing brawl with Baltimore reliever Kevin Gregg as the Red Sox routed the Orioles 10-3 on Friday night.

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Ortiz and Gregg exchanged a flurry of punches in the eighth, but neither connected before they were separated as both benches and bullpens emptied for the second time in the inning.

Moments before the fight, Ortiz started toward the mound after taking a second straight pitch inside from Gregg. The benches and bullpens emptied, but nothing developed and Ortiz stepped back into the batter's box.

Gregg had thrown two pitches inside to Ortiz, who started toward the mound after the second.

Gregg then got Ortiz to pop out and shouted something to the Boston slugger, who charged and met Gregg about halfway between the mound and first base line.

Umpire Mike Estabrook, who had already ejected Gregg, couldn't quite reach Ortiz in time to stop him. The benches and bullpens cleared again and took several minutes to settle down as Boston fans cheered "Pa-pi!"

Ortiz and catcher Jarrod Saltalamacchia were both ejected for Boston. Gregg and reliever Jim Johnson were tossed for the Orioles.