An adult and four children have died in a raging two-alarm fire in Baltimore City that also left one other person and two firefighters injured.

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Baltimore City Fire chief Kevin Cartwright says the blaze broke out in a two-story row house along the 5600 block of Denwood Avenue shortly after 2 a.m. Thursday.

Responding firefighters found flames quickly spreading to the second floor of the home, Cartwright says.

Five people are confirmed dead. Family members say that a grandmother, identified as Nancy Worrell, 55, died in the fire. They say her husband jumped from the home, broke his back and is covered in third degree burns. He was reportedly transported to Johns Hopkins Bayview Hospital.

The Baltimore Sun, citing a family member, identified the deceased children as Worrell's grandchildren K'Niyah Scott, 2, Daryl Stewart, 4, and Takyla Manley, 7, and great-grandson James Holden, Jr., 1.

Two firefighters also suffered minor injuries when one of them fell from the second floor of the residence and landed on top of a fellow firefighter, Cartwright says.

The family said four people were able to escape the fire, including the mother of the two and four-year-olds. She was holding a 2-month-old baby boy when she jumped out the living room window, they said. 

Debbie Boyd's sister and four nieces and nephews died in the fire. She says she's trying to be strong for the rest of the family but it's a struggle.

“No death is easy, but 5? That's really hard,” Boyd says. “I mean how do you handle this how you do that … how can you?”

The cause of the fire remains under investigation.