It will be a tough winter for two Colorado children—because they are allergic to the cold.

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Connor and Taylor Frankenfeld have been diagnosed with Cold Urticaria. They bundle up when they go to school and can’t leave the house when temperatures are in the single digits.

Experts say Cold Urticaria affects a small number of people, mostly in the southern United States. It is not clear what causes it, but it can be treated with anti-histamines.